Disease's type
GDM
Experimental grouping
GDM(n=14),Normal Glucose Tolerance(n=14)
GPT's summary
This research aimed to identify and validate key genes in the placenta that could be related to gestational diabetes mellitus (GDM). Two datasets, GSE70493 and PRJNA646212, were analyzed for differentially expressed genes (DEGs), leading to the identification of 20 common DEGs. These genes were then validated in placental tissues from GDM patients and in a cellular model using HTR8/SVneo cells treated with high glucose. The findings indicated changes in gene expression patterns that correlated with GDM, suggesting their potential use as biomarkers for the prevention and management of GDM, as well as for improving pregnancy outcomes and fetal prognosis.
RF's name
Integrin Subunit Alpha X
Sample's type
Placental Tissue and HTR8/SVneo Cell Line.
Gestational weeks
At the time of cesarean delivery
Experiemental methods
RT-qPCR
Title
Analysis, validation, and discussion of key genes in placenta of patients with gestational diabetes mellitus
Evidence's type
Risk factor
Year
2023
Journal
Experimental Biology and Medicine
PMID