Disease's type
GDM
Experimental grouping
GDM(n=6),Normal Glucose Tolerance(n=6)
GPT's summary
The study investigates the impact of gestational diabetes mellitus (GDM) on the proteome of maternal omental adipose tissue using 2D-DIGE and mass spectrometry. It identifies 14 differentially expressed proteins, including up-regulation of COL6A2, FIBB, LUM, and S100A9, and down-regulation of 10 others, highlighting the involvement of these proteins in inflammation, lipid and glucose metabolism, and oxidative stress. The findings support the role of visceral adiposity in the pathogenesis of GDM.
RF's name
S100 Calcium Binding Protein A9
Sample's type
Omental Adipose Tissue
Gestational weeks
At the time of term Caesarean section
Experiemental methods
Western Blotting
Title
2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue
Evidence's type
Risk factor
Year
2013
Journal
Journal of Endocrinology
PMID