Disease's type
GDM
Experimental grouping
GDM(n=8),Normal Glucose Tolerance(n=10)
GPT's summary
This research aimed to explore the differences in the exosomal proteome of 24-hour urine samples collected from pregnant women with GDM, PGD, and controls at 20 weeks of pregnancy. The study identified an increase in S100A9 protein in GDM and PGD subjects, which was linked to maternal obesity and macrosomia in newborns. The findings suggest that urinary exosome proteomics can provide non-invasive insights into the pathophysiology of diabetes during pregnancy and help differentiate between types of diabetes on a pathway level.
RF's name
S100 Calcium Binding Protein A9
Sample's type
Exosome Protein of 24 hour Urine
Gestational weeks
At 20th gestational weeks
Experiemental methods
Western blotting
Machine learning algorithms
Negative binomial generalized linear models
Title
Proteomic analyses of Urine Exosomes reveal New Biomarkers of Diabetes in Pregnancy
Evidence's type
Risk factor
Year
2016
Journal
Madridge Journal of Diabetes
PMID