Disease's type
GDM
Experimental grouping
GDM(n=28),Normal Glucose Tolerance(n=53)
GPT's summary
"The study investigates the regulation of serum miRNAs in South African women with gestational diabetes mellitus (GDM), focusing on miRNAs previously linked to GDM in other populations. It found that miR-20a-5p and miR-222-3p were significantly downregulated in GDM patients. Logistic regression analysis indicated that miR-20a-5p and additional risk factors predict GDM. Functional analysis suggests miR-20a-5p's involvement in metabolic pathways, particularly insulin signaling. While miR-20a-5p shows promise as a biomarker for GDM, it may require incorporation into broader miRNA panels for improved specificity.
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RF's name
hsa-miR-20a-5p
Sample's type
Serum
Gestational weeks
13th to 31th gestational weeks
Experiemental methods
miScript miRNA PCR Arrays
Machine learning algorithms
Logistic Regression
Title
Decreased Expression of Circulating miR-20a-5p in South African Women with Gestational Diabetes Mellitus
Evidence's type
Risk factor
Year
2018
Journal
Mol Diagn Ther
PMID