Disease's type
GDM
Experimental grouping
"Discovery set: GDM(n=12),Normal Glucose Tolerance(n=12)
Validation set: GDM(n=102),Normal Glucose Tolerance(n=101)
Prediction set: GDM(n=30),Normal Glucose Tolerance(n=60)"
Validation set: GDM(n=102),Normal Glucose Tolerance(n=101)
Prediction set: GDM(n=30),Normal Glucose Tolerance(n=60)"
GPT's summary
This study aimed to identify and validate differentially expressed miRNAs in plasma exosomes from women with GDM and those with NGT. Using high-throughput sequencing and real-time qPCR, the researchers found 22 exosomal miRNAs, with five significantly altered miRNAs (miR-423–5p, miR-122–5p, miR-148a-3p, miR-192–5p, and miR-99a-5p). These miRNAs are involved in insulin and AMPK signaling pathways, suggesting their role in metabolic regulation in GDM. The five miRNAs showed a high accuracy (AUC=0.82) in predicting GDM early.
RF's name
hsa-miR-99a-5p
Sample's type
Plasma Exosomes
Gestational weeks
10th to 16th gestational weeks
Experiemental methods
qRT-PCR
Title
Plasma Exosomal miRNAs Associated With Metabolism as Early Predictor of Gestational Diabetes Mellitus
Evidence's type
Risk factor
Year
2022
Journal
Diabetes
PMID