C-pep

This study explored the association between fasting serum C-peptide concentrations in early pregnancy and the risk of gestational diabetes mellitus (GDM) in a nested case-control cohort of 436 Chinese women. Results showed that C-peptide levels significantly decreased from the first to the second trimester in women with normal glucose tolerance (NGT). However, higher C-peptide levels during the first and second trimesters were associated with a markedly increased risk of GDM, with odds ratios of 2.38 and 3.07, respectively. The predictive capacity of C-peptide was substantial, with areas under the ROC curves of 80.4% and 82.4% for the first and second trimesters. These findings suggest that fasting serum C-peptide is a strong predictor of GDM and could aid in early detection and intervention.