Disease's type
GDM
Experimental grouping
GDM(n=169),Normal Glucose Tolerance(n=1904);Q1(13.0–38U/L,n=519),Q2 (38–44U/L,n=518),Q3 (44–50U/L,n=517),Q4 (>50U/L,n=519)
GPT's summary
This study explored the relationship between early maternal alkaline phosphatase (ALP) levels and the risk of gestational diabetes mellitus (GDM) and glucose regulation. Among 2,073 pregnant women, higher ALP levels, even within the normal range, were found to be positively associated with an increased risk of GDM. Every 10 U/L increase in ALP was linked to higher fasting blood glucose (FBG) and 1-hour post-load blood glucose (PBG) levels. Additionally, elevated ALP levels were associated with an increased risk of isolated impaired fasting glucose (i-IFG) and impaired glucose tolerance (i-IGT). These findings suggest that early maternal ALP levels could serve as a predictor for GDM risk.
RF's name
Alkaline Phosphatase
Sample's type
Serum
Gestational weeks
16±2 gestational weeks
Experiemental methods
Colorimetric method
Title
Early maternal circulating alkaline phosphatase with subsequent gestational diabetes mellitus and glucose regulation: a prospective cohort study in China
Evidence's type
Risk factor
Year
31115769
Journal
Endocrine
PMID