hsa-miR-149-3p

This research explores the variation in miRNA profiles within exosomes derived from maternal and placental sources during early pregnancy in relation to pancreatic β-cell function. It uses a nested case-control design to compare miRNA expression between women who remain normoglycemic and those who later develop GDM. The findings suggest that specific miRNAs, such as hsa-miR-149-3p, hsa-miR-455-3p, hsa-miR-3665, and hsa-miR-6727-5p, are related to insulin secretion, lipolysis, adipocytokine signaling, and immune tolerance mechanisms, providing insights into potential biomarkers for GDM.