| Literature link | GPT Summary | Evidence category | Disease type |
|---|---|---|---|
| 33158950 | This study aimed to explore the association between early pregnancy levels of folate and vitamin B12 and the risk of gestational diabetes mellitus (GDM). The research was conducted using data from the Shanghai Preconception Cohort Study, which included pregnancies with red blood cell (RBC) folate and vitamin B12 measurements taken between 9 and 13 weeks of gestation. GDM was diagnosed between 24 and 28 weeks. The study found that both RBC folate and vitamin B12 levels were significantly higher in pregnancies that developed GDM compared to those without GDM, and these biomarkers were positively correlated with 1-hour and 2-hour serum glucose levels. Daily folic acid supplementation in early pregnancy was associated with an increased risk of GDM, with an odds ratio (OR) of 1.73. Pregnancies with RBC folate levels ≥600 ng/mL had a 1.60-fold higher odds of GDM compared to those with RBC folate levels <400 ng/mL. Additionally, each 100 pg/mL increase in vitamin B12 was associated with a 1.14-fold increase in GDM risk. However, no significant association was found between the balance of folate to vitamin B12 or serum folate levels and GDM. The findings suggest that higher maternal RBC folate and vitamin B12 levels in early pregnancy are significantly associated with an increased risk of GDM. |
Risk factor |
GDM |
| 36501046 | This study aimed to assess the association between maternal B vitamins in early pregnancy and the risk of gestational diabetes mellitus (GDM). A cohort of 1,265 pregnant women was recruited between 8 to 15 weeks of gestation in Shanghai, China, in 2021-2022. The final analysis included 1,065 pregnancies with both serum B vitamin measurements at recruitment and glucose measurements at 24-28 weeks of gestation. The study found that GDM occurred in 121 women (11.36%). Multivariate logistic regression models showed an increasing risk of GDM across serum vitamin B1 quartiles (p-Trend = 0.001). Women in the upper two quartiles of serum vitamin B6 had about twice the odds of developing GDM compared to those in the lowest quartile. Conversely, women with serum vitamin B12 levels greater than 150 pmol/L had lower odds of GDM compared to those with levels less than 150 pmol/L (p = 0.005). Restricted cubic spline regression models indicated that serum vitamin B6 and B12 were associated with GDM risk in a nonlinear fashion. In conclusion, the study found that higher maternal serum levels of vitamin B1 and B6 in early pregnancy were linked to an increased risk of GDM, while sufficient vitamin B12 levels were associated with a lower risk. | Risk factor | GDM |
RF's name
Vitamin B12
RF's type
Vitamin