RBC

By admin , 18 September 2025
Go ontology
Literature evidence
Literature link GPT Summary Evidence category Disease type
38343583 This study aimed to investigate the dynamic changes in hematological parameters from the first trimester (6-12 weeks) to the second trimester (24-28 weeks) and their associations with the risk of gestational diabetes mellitus (GDM). Conducted as a prospective double-center study in Beijing, China, the research involved 1027 pregnant women, with 258 developing GDM. Hematological parameters such as white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB), and platelets (PLT) were measured at multiple time points. The study found that WBC levels gradually increased, while RBC, HGB, and PLT decreased from the first to the second trimester. After adjusting for confounding factors, higher levels of RBC, HGB, and PLT were positively associated with GDM risk, whereas WBC was associated with GDM risk only in the first trimester. Furthermore, these hematological parameters correlated with fasting insulin levels in early pregnancy. The findings suggest that higher levels of hematological parameters in both early and middle pregnancy are associated with glucose metabolism and the risk of GDM, highlighting their potential role as biomarkers for early GDM prediction. Risk factor GDM
Other information links
KEGG pathway
Porphyrin metabolism, Hematopoietic cell lineage, Glycolysis / Gluconeogenesis, Pentose phosphate pathway
Relationship with GDM:
The changes of WBC (a), RBC (b), HGB (c), and PLT (d) from early to middle pregnancy in the non-GDM and GDM group. Data were demonstrated by mean and 95% CI.
Figure's link
38343583
Expressing in whole blood:
↑
RF's name
Red Blood Cell Count
RF's type
Complete blood count