ALP | eGDMD

By admin , 18 September 2025

Go ontology

Literature evidence

Literature link	GPT Summary	Evidence category	Disease type



38836232	This study aimed to investigate the relationship between maternal liver biomarkers and the risk of gestational diabetes mellitus (GDM), as well as the potential causality and interactions between liver biomarkers and lipid levels on GDM risk. Data were obtained from the ongoing Zhoushan Pregnant Women Cohort, which included 9,148 pregnant women. Liver function tests, including ALT, AST, GGT, ALP, and hepatic steatosis index, were measured in early pregnancy, and GDM screening was completed. The results revealed that the highest quartile of liver function index (LFI) was significantly associated with an increased risk of GDM, with odds ratios (OR) ranging from 1.29 to 3.15, particularly in relation to abnormal postprandial blood glucose levels. Additionally, Mendelian randomization (MR) analysis confirmed a causal link between ALT levels and GDM (OR = 1.28, 95% CI: 1.05-1.54). Furthermore, a significant interaction between AST/ALT and triglycerides (TG) was observed (P interaction = 0.026). In conclusion, elevated LFI levels in early pregnancy were strongly associated with an increased risk of GDM, with a positive causal relationship between ALT and GDM. These findings suggest that liver biomarkers, particularly ALT, may serve as useful indicators for early GDM prediction.	Risk factor	GDM
31115769	This study explored the relationship between early maternal alkaline phosphatase (ALP) levels and the risk of gestational diabetes mellitus (GDM) and glucose regulation. Among 2,073 pregnant women, higher ALP levels, even within the normal range, were found to be positively associated with an increased risk of GDM. Every 10 U/L increase in ALP was linked to higher fasting blood glucose (FBG) and 1-hour post-load blood glucose (PBG) levels. Additionally, elevated ALP levels were associated with an increased risk of isolated impaired fasting glucose (i-IFG) and impaired glucose tolerance (i-IGT). These findings suggest that early maternal ALP levels could serve as a predictor for GDM risk.	Risk factor	GDM