| Literature link | GPT Summary | Evidence category | Disease type |
|---|---|---|---|
| 33553034 | This study investigated the role of adipocytokines (adiponectin, resistin, interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]) as potential predictive markers of gestational diabetes mellitus (GDM). Pregnant women with normal BMI were recruited at 12–14 weeks of gestation and monitored until 24–28 weeks. Blood samples were analyzed for adipocytokines, insulin, and glucose levels to calculate insulin resistance (HOMA-IR). Results showed significantly higher levels of HOMA-IR, resistin, IL-6, and TNF-alpha, and lower levels of adiponectin in GDM subjects compared to healthy controls, both at 12 and 24 weeks. Additionally, adipocytokine levels changed significantly from 12 to 24 weeks in both groups, with increases in resistin, IL-6, and TNF-alpha, and a decrease in adiponectin. These findings suggest that adipocytokines play a role in the pathophysiology of GDM and could serve as early predictive markers for its development. |
Risk factor |
GDM |
| 31836012 | This study investigated the roles of adipokines (leptin, resistin, and visfatin) and lipid profiles in predicting gestational diabetes mellitus (GDM) during the first trimester. Significant elevations in leptin, resistin, and visfatin levels, as well as dyslipidemia, were observed in women who later developed GDM compared to those who did not. The predictive accuracy for GDM, reflected by the area under the receiver operating characteristic curves (AUCs), was 0.812 for leptin, 0.836 for resistin, and 0.799 for visfatin. Elevated leptin (OR = 1.166), resistin, and visfatin levels were strongly associated with GDM risk. These findings suggest that hyperleptinemia, hyperresistinemia, and hypervisfatinemia during early pregnancy can serve as effective biomarkers for early prediction and prevention of GDM. | Risk factor | GDM |
| KEGG pathway |
|---|
| Insulin resistance, Type II diabetes mellitus |
RF's name
Resistin
RF's type
protein