| Literature link | GPT Summary | Evidence category | Disease type |
|---|---|---|---|
| 35000498 | This study investigated the predictive value of first-trimester maternal neutrophil levels for gestational diabetes mellitus (GDM) in a cohort of 731 singleton pregnant women. Neutrophil count was found to outperform other inflammatory markers, such as the neutrophil-to-lymphocyte ratio and white blood cell count, in predicting GDM. After adjusting for pre-pregnancy BMI, family history of diabetes, and age, higher neutrophil counts were associated with increased fasting and 1-hour postprandial blood glucose levels. Logistic regression analysis revealed that women in the highest tertile of neutrophil count (6.28–14.73 × 10?/L) had a 1.85-fold higher risk of developing GDM compared to those in the lowest tertile (1.47–4.82 × 10?/L). These findings suggest that elevated neutrophil levels in early pregnancy are associated with an increased risk of GDM and could serve as a useful early predictive marker. |
Risk factor |
GDM |
| 32332157 | This study explored the predictive role of inflammatory blood cell parameters in gestational diabetes mellitus (GDM) and pregnancy outcomes in a cohort of 258 women with GDM and 1,154 without. Among the parameters analyzed, first-trimester neutrophil count demonstrated superior predictive ability for GDM compared to total white blood cell count and the neutrophil-to-lymphocyte ratio. Higher neutrophil counts were associated with a stepwise increase in GDM incidence, glucose and glycosylated hemoglobin levels, HOMA-IR, macrosomia incidence, and newborn weight. Neutrophil count was positively correlated with prepregnancy BMI, insulin resistance (HOMA-IR), and newborn weight and was identified as an independent risk factor for GDM development, irrespective of a prior GDM history. A significant linear association between GDM risk and neutrophil count was observed when the neutrophil count exceeded 5.0 × 10?/L. These findings highlight the potential utility of first-trimester neutrophil count as an early biomarker for GDM and its associated adverse pregnancy outcomes. |
Risk factor |
GDM |
| 20081861 | Lung cancer remains the leading cause of cancer-related mortality worldwide, with increasing evidence suggesting that tumor-associated inflammatory cells influence tumor progression. This study investigates the role of neutrophil elastase (NE), encoded by Elane, in lung adenocarcinoma using the loxP-Stop-loxP K-ras(G12D) (LSL-K-ras) mouse model. Deletion of Elane significantly reduced tumor burden and improved survival, with all LSL-K-ras-Elane(+/+) mice succumbing to disease while none of the Elane-deficient mice died. Mechanistically, NE directly promotes tumor cell proliferation by entering the endosomal compartment of lung adenocarcinoma cells, where it degrades insulin receptor substrate-1 (IRS-1). This degradation enhances phosphatidylinositol 3-kinase (PI3K) association with platelet-derived growth factor receptor (PDGFR), driving tumor growth. The inverse relationship between NE and IRS-1 observed in the mouse model was also confirmed in human lung adenocarcinomas, underscoring the translational relevance of these findings. This study not only identifies IRS-1 as a key regulator of PI3K signaling in malignant cells but also provides the first evidence of a secreted proteinase penetrating intracellular compartments to modulate signaling pathways, offering new therapeutic insights into lung cancer progression. | Mechanism | Insulin resistance |
RF's name
Absolute Neutrophil Count
RF's type
Complete blood count