| Literature link | GPT Summary | Evidence category | Disease type |
|---|---|---|---|
| 38085430 | This study developed and validated an early pregnancy risk prediction model for gestational diabetes mellitus (GDM) based on a cohort of 6000 pregnant women. Independent risk factors identified for GDM included age, pre-pregnancy BMI, glycosylated hemoglobin (HbA1c), blood uric acid (UA), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). The model demonstrated good predictive performance, with an AUC of 0.803 in the training cohort and 0.782 in the validation cohort, indicating reliable sensitivity and specificity. These findings suggest that combining maternal demographic and laboratory indicators in early pregnancy can help identify high-risk women, providing a basis for early screening and intervention. | Risk factor | GDM |
| 39075387 | This nested case-control study investigated the relationship between lipid profiles, lipid ratios, and gestational diabetes mellitus (GDM) in early and mid-pregnancy, involving 1586 pregnant women, of whom 741 were diagnosed with GDM. Higher levels of triglycerides (TG), ApoA1, ApoB, LDL-c, triglyceride glucose index, TG/HDL-c, and TC/HDL-c ratios in early pregnancy were positively associated with an increased risk of GDM, while HDL-c levels were negatively associated. These associations persisted in mid-pregnancy, with stably high levels of triglyceride glucose index, TG/HDL-c, and TC/HDL-c from early to mid-pregnancy significantly increasing GDM risk. Conversely, consistently high HDL-c levels were associated with a reduced GDM risk. These findings suggest the clinical potential of lipid measures for early identification of women at high risk for GDM. | Risk factor | GDM |
| 28436169 | This nested case-control study examined longitudinal changes in lipid profiles during pregnancy and their association with gestational diabetes mellitus (GDM) risk. Among 107 GDM cases and 214 controls, plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. Higher triglyceride and lower HDL-C concentrations in early (10-14 weeks) and mid-pregnancy (15-26 weeks) were significantly associated with an increased GDM risk, with adjusted odds ratios (aORs) of 6.57 for triglycerides and 0.23 for HDL-C in mid-pregnancy. Total cholesterol and LDL-C levels were not associated with GDM risk. These findings suggest that early and mid-pregnancy triglyceride and HDL-C levels may serve as biomarkers for GDM risk. | Risk factor | GDM |
| KEGG pathway |
|---|
| Cholesterol metabolism, Lipid and atherosclerosis |
RF's name
High Density Lipoprotein Cholesterol
RF's type
Lipid metabolism indicator