SHBG

By admin , 18 September 2025
Go ontology
Literature evidence
Literature link GPT Summary Evidence category Disease type
31270755 Gestational diabetes mellitus (GDM) is characterized by glucose intolerance arising during pregnancy, with insulin resistance being a central feature. Sex hormone-binding globulin (SHBG) is implicated in insulin resistance and has been identified as a risk factor for GDM. This study investigates the regulatory role of SHBG in glucose metabolism via glucose transporters (GLUTs). Using an insulin resistance cell model, SHBG expression was found to be reduced, while GLUT1 was elevated and GLUT3/GLUT4 were diminished compared to normal control cells. Overexpression of SHBG in insulin-resistant cells downregulated GLUT1 while upregulating GLUT3 and GLUT4 at both mRNA and protein levels, as confirmed by real-time PCR, western blot, and immunofluorescence analysis. These findings suggest that SHBG influences glucose metabolism by modulating GLUT expression, potentially offering a therapeutic target for improving insulin resistance in GDM. However, the precise mechanisms underlying SHBG-mediated regulation of GLUTs remain unclear and warrant further investigation. Mechanism Insulin resistance
Other information links
KEGG pathway
Insulin signaling pathway, Insulin resistance, Estrogen Signaling Pathway, Adipocytokine signaling pathway
Relationship with GDM:
GDM association with SHBG concentrations
Figure's link
24561392
Expressing in serum:
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RF's name
Sex Hormone Binding Globulin
RF's type
Estrogen synthesis indicators